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KMID : 0882420100780030386
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Korean Journal of Medicine
2010 Volume.78 No. 3 p.386 ~ p.390
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A case of myeloid neoplasm with the PDGFRB rearrangement and eosinophilia
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Jang Sang-Eon
Kang Hye-Jin
Jang Yoon-Hwan
Lee Dong-Soon
Kim Hyeon-Tae
Koh Kyung-Won
Yang Sung-Hyun
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Abstract
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Myeloid neoplasm with the platelet-derived growth factor receptor beta (PDGFRB) rearrangement is a myeloproliferative neoplasm. Patients with this disease often have prominent eosinophilia or monocytosis and the presence of t(5;12)(q31~33;p12) or a variant translocation with expression of an ETV6-PDGFRB fusion gene or the PDGFRB rearrangement. We report an 82-year-old woman with a myeloid neoplasm, with the PDGFRB rearrangement, who presented with a dry cough, eosinophilia and thrombocytosis. The chromosome study of the bone marrow showed 46,XX,ins(1;5)(q22;q33q13.3), and fluorescence in situ hybridization (FISH) analysis revealed rearrangement of the PDGFRB gene. The patient was successfully treated with low-dose imatinib.
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KEYWORD
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Myeloid neoplasm, PDGFRB rearrangement, Eosinophilia, Imatinib mesylate
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